Jumat, 05 Agustus 2011

Lactose intolerance

Is the inability to digest lactose, a sugar found in milk and other dairy products and is caused by a deficiency of the enzyme lactase.

Alternative NamesMilk intolerance, lactase deficiency, disaccharidase deficiency, dairy product intolerance\


 Causes and Risk FactorsLactose intolerance occurs when the intestine does not produce enough lactase enzyme. Babies' bodies make this enzyme so they can digest milk, including breast milk. Before humans became farmers and processed dairy products, most people do not continue to drink milk in your life, so that did not produce lactase after early childhood.
People from cultures in which the consumption of milk and dairy products in adults occurred earliest are less likely to suffer from lactose intolerance than those belonging to villages where the consumption of dairy farming began more recently. As a result, lactose intolerance is more common in Asian, African American, Native American, and Mediterranean populations of northern and western Europe.
Lactose intolerance can begin at different times in life. In Caucasians, it usually starts to affect children older than 5 years, while the black people, the condition often occurs up to two years old.
When people with lactose intolerance eat or drink dairy products, may have symptoms such as bloating, excessive intestinal gas, nausea, diarrhea and abdominal cramps.
Lactose intolerance is not dangerous and is very common in adults. Approximately 30 million American adults have some degree of lactose intolerance by age 20 years.
Lactose intolerance is sometimes seen in premature babies and babies born at full term generally do not show signs of this condition until they are at least 3 years of age.
The fact of not having milk in the diet can cause a shortage of calcium, vitamin D, riboflavin and protein, so you need a milk substitute. Soy preparations are adequate substitutes for bottle babies under 2 years and for children toddlers, soy milk and rice are good alternatives. Older children may also consume cow's milk treated with lactase. Goat's milk is low in lactose, but should only be used with children if properly fortified with vitamins and essential amino acids.
Most people with low lactase can tolerate 2 to 4 ounces of milk at one time (up to half a cup), but larger portions (8 ounces) can cause problems for those with some degree of intolerance to milk.
Lactase deficiency may also occur as a result of intestinal diseases such as celiac sprue and gastroenteritis, or also manifest after intestinal surgery. This may be a temporary lactase deficiency due to bacterial or viral infections, especially in children, when injured cells lining the intestine. 

Symptoms
  •     Abdominal cramps
  •     Distension
  •     Flatulence
  •     Weight Loss
  •     Malnutrition
  •     Slow growth
  •     Bloating
  •     Diarrhea
  •     Floating stools
  •     Foul-smelling stools

Symptoms often occur after the ingestion of dairy products and often relieved by the suspension of the same. Large doses of milk products may cause worse symptoms.


Signs and tests

  •     Test for stool-reducing substances
  •     Proof of lactose tolerance
  •     Breath test for lactose-hydrogen
  •     Small bowel biopsy

Treatment
Symptoms usually are relieved with the suspension of dairy products in the diet, in which case it should be incorporated into food sources of calcium.
Usually can tolerate fermented milk products like yogurt. Sometimes, patients tolerate goat's milk, but it is recommended taken with meals, not alone. Also, consider that the butter milk and cheeses have less lactose than milk itself.
It may help to consumption of milk and lactose-free dairy products. Also, you can add lactase enzymes to regular milk or take them in capsule or chewable tablet form.
You should read food labels, because the lactose found in some non-milk products, including some beers. 

Expectations (prognosis)Usually, symptoms disappear once you stop consuming dairy products in the diet. 
ComplicationsPossible complications include weight loss and malnutrition. 
Calling your health careSeek medical attention if a child or adult has symptoms of lactose intolerance in order to seek food substitutes. Even when symptoms worsen or do not improve with treatment or if new symptoms. 
PreventionThere is no known way to prevent the development of lactose intolerance. However, if you have this condition, you can avoid or limit consumption of dairy products to reduce or eliminate symptoms.



source: clinicadam.com
READ MORE - Lactose intolerance

Side effects of medications used to treat seizures

Seizures
It is a sudden change in behavior due to an excessive electrical activity in the brain. 

ConsiderationsDepending on the part of the brain affected, a wide variety of possible symptoms of a stroke or seizure. Many types of seizures cause loss of consciousness with twitching or shaking of the body. However, some seizures consist of staring spells that can easily go unnoticed. Occasionally, they can cause temporary abnormal sensations or visual disturbances.
Usually, attacks or seizures can be classified into "simple" (no change in level of consciousness) or "complex" (change in level of consciousness). Can also be classified as generalized (whole body affected) or focal (affecting only one part or side of the body).
Epilepsy is a chronic disorder with recurrent seizures. Some types of epilepsy are hereditary.
See also:

  •     Epilepsy
  •     Crisis petit mal
  •     Tonic-clonic (grand mal seizure)
  •     Partial (focal)
  •     Temporal lobe seizures
  •     Febrile seizure (convulsions in children with high fever)

Causes
Any condition that results in abnormal electrical excitation of the brain can trigger a seizure, including:

  •     Epilepsy
  •     Injury or trauma to the head
  •     Infection (brain abscesses, meningitis)
  •     Brain tumor
  •     Stroke

Also, any medical condition that irritates brain cells. Medical conditions that commonly cause seizures include:

  •     Hypoglycemia (low blood sugar)
  •     Drug use (especially cocaine or stimulants)
  •     high fever (fever convulsions in children)
  •     Alcohol withdrawal

Home Care
People with epilepsy should always wear a medical alert tag.
Most seizures are self-limiting and stop by themselves after various periods of time. However, the victim may get hurt, suck some food, liquid or vomiting, or not getting enough oxygen. During a seizure is important to protect the victim from injury. He turns the head of the victim if there is vĂ³mito.Ver first aid in case of attack.
After a convulsion, most people go into a deep sleep. Do not stop to sleep. It is possible that after awakening disoriented for some time.
Stay with the person until recovery or until professional medical help arrives. Meanwhile, monitor their pulse, breathing rate, blood pressure.

  •     DO NOT restrain the victim
  •     DO NOT place anything between the teeth during a seizure (including your fingers)
  •     DO NOT move the victim unless it is in danger or near something hazardous
  •     DO NOT try to stop the seizure of the victim, the person can not control the seizure and did not realize what is happening.
  •     DO NOT give anything by mouth to the victim until the convulsions have stopped and the person is fully conscious and alert

Some patients with epilepsy, they may implant a vagus nerve stimulator in the chest, which may stop the seizures will activate this device. Other patients may be prescribed medication to administer rectally during a seizure. Do not give anything by mouth, even medications. 

Call your doctor ifInform your doctor about all seizures (even if mild). People affected by epilepsy or recurrent seizures should visit the doctor to adjust medications or other instructions.
If this is the first time that a seizure or if there is a new type of seizure, bring the patient to the doctor immediately, as these symptoms may indicate a terminal condition such as stroke or meningitis.
PreventionThere is no specific way to prevent attacks. If necessary, use of a helmet to prevent injury, which will reduce the chances of a brain injury and subsequent attacks. Avoid recreational drugs. People with epilepsy should take medication as instructed by your doctor and avoid taking excessive amounts of alcohol.What to expect at the doctor's
The doctor does a physical exam and ask questions that help you learn the cause of the attack. Here are some of the questions:

  •     Did it happen or start on one side of the body?
  •     There movement of muscles and if so, what was the pattern?
  •     Are there risk factors (such as recent head injury)?
  •     Are remained conscious during the attack?
  •     How long did the attack?
  •     What is the frequency of the seizures?
  •     Is there any warning (aura) of the attack?
  •     Were there any other symptoms (visual changes, abnormal smells)?

You can perform the following tests:

  •     Head CT or MRI of the head
  •     EEG
  •     Lumbar puncture
  •     Blood tests

Often medications are prescribed which must be taken with great precision following your doctor's instructions. Family members should observe and keep a diary of all attacks in order to get proper treatment.
People with uncontrolled seizures should not drive. Each state has a different law that determines which patients are allowed to drive. People who suffer from seizures should not swim or ride a bike without company. 

ReferencesGoetz, CG. Textbook of Clinical Neurology. 2nd ed. St. Louis, MO: WB Saunders, 2003: 1158-1160.
Marx J. Rosen's Emergency Medicine: Concepts and Clinical Practice. 5th ed. St. Louis, Mo: Mosby, 2002:145-149, 1445.
Hirtz D, Ashwal S, Berg A, et al. Practice parameter: Evaluating a first seizure in children nonfebrile: Report of the Quality Standards Subcommittee of the American Academy of Neurology, the Child Neurology Society, and the American Epilepsy Society. Neurology. 2000, 55, 616-623.
READ MORE - Side effects of medications used to treat seizures

Acidosis

It is a condition characterized by excess acid in body fluids. 
Causes and Risk FactorsThe acid-base balance of the body (pH) is regulated by the kidneys and lungs. Acidosis is caused by a buildup of acid or a significant loss of bicarbonate. The main types of acidosis are respiratory acidosis and metabolic acidosis.
The human body is programmed to correct for either respiratory or metabolic acidosis to maintain normal pH. For example, if acidosis is caused by excess carbon dioxide is an acid that the body will correct the pH by retaining bicarbonate, which is a basis.
Respiratory acidosis develops when there is excessive amounts of carbon dioxide in the body, due mainly to a decrease in breathing. Other names for this include hypercapnic acidosis and carbon dioxide acidosis.
There are several types of metabolic acidosis: lactic acidosis, also called diabetic ketoacidosis and DKA develops when ketone bodies accumulate during uncontrolled diabetes mellitus.
Hyperchloremic acidosis results from excessive loss of sodium bicarbonate from the body, as for example with severe diarrhea.
Lactic acidosis is a buildup of lactic acid, which can be caused by many conditions, including prolonged lack of oxygen (for example, shock, heart failure or severe anemia), prolonged exercise, seizures, hypoglycemia (low sugar blood), alcohol, liver failure, malignancy, or certain medications like salicylates.
Other causes of metabolic acidosis include severe dehydration resulting in decreased muscle perfusion (decreased blood flow), kidney disease (see distal renal tubular acidosis and proximal renal tubular acidosis) and other metabolic diseases.


SymptomsSee the specific types of acidosis.Signs and tests
An analysis of blood gases or blood chemistry (such as basic blood chemistry analysis), will confirm acidosis in most cases. Other tests may be required to determine the cause of acidosis. 

TreatmentTreatment depends on the cause. See specific types of acidosis.Expectations (prognosis)
Acidosis can be dangerous if not treated. Many of the causes respond well to treatment. 

ComplicationsSee the specific types of acidosis.Calling your health care
Although there are several types of acidosis, all will cause symptoms that require medical treatment. See the specific types of acidosis.


PreventionPrevention or treatment of the underlying causes may prevent some cases of acidosis.



source: clinicadam.com
READ MORE - Acidosis

Acute renal failure

It is the sudden loss of the ability of the kidneys to remove waste and concentrate urine without losing electrolytes.

Alternative NamesKidney failure, acute kidney failure, kidney failure, kidney failure


Causes and Risk FactorsThere are many possible causes of kidney damage, such as:

  •     Decreased blood flow can occur with extremely low blood pressure caused by trauma, surgery, serious illness, septic shock, hemorrhage, burns or dehydration.
  •     Acute tubular necrosis (ATN)
  •     Infections that directly injury the kidney such as acute pyelonephritis or septicemia.
  •     Urinary tract obstruction (obstructive uropathy).
  •     Autoimmune kidney disease such as interstitial nephritis or acute nephritic syndrome.
  •     Disorders that cause clotting within the thin blood vessels of the kidney, as
  •         idiopathic thrombocytopenic purpura (ITP)
  •         transfusion reaction
  •         malignant hypertension
  •         Scleroderma
  •         Hemolytic uremic syndrome
  •         disorders resulting from childbirth as bleeding, placental abruption or placenta previa

Symptoms

  •     Decreased urine output (oliguria)
  •     No urine output (anuria)
  •     Excessive nighttime urination
  •     Swollen ankles, feet and legs
  •     Generalized swelling from fluid retention
  •     Decreased sensation, especially in the hands or feet
  •     Loss of appetite
  •     Metallic taste in mouth
  •     Persistent hiccups
  •     Changes in mental status or mood
  1.         agitation
  2.         sleepiness
  3.         lethargy
  4.         delirium or confusion
  5.         coma
  6.         fluctuating mood
  7.         difficulty paying attention
  8.         hallucinations
  •     Slow, sluggish movement
  •     Seizures
  •     Hand tremor
  •     Nausea or vomiting that can last for days
  •     Tendency to bruising
  •     Prolonged bleeding
  •     Nosebleed
  •     Bloody
  •     Flank pain
  •     Fatigue
  •     Bad breath
  •     High blood pressure

Signs and tests
The exams and tests can help diagnose acute kidney failure and rule out other problems that can affect kidney function.
Many patients have generalized swelling caused by fluid retention. The doctor uses a stethoscope to listen to your heart and lungs. During this procedure, you can hear a heart murmur, crackles in the lungs, inflammation of the lining of the heart (pericarditis), or other sounds related to the presence of extra fluid.
The results of laboratory tests may change suddenly (within a few days to 2 weeks):

  •     Urine tests (urine analysis) may be abnormal
  •     The levels of serum creatinine, urea, ability to creatinine clearance and serum potassium may increase
  •     Arterial blood gas and blood chemistry analysis may show metabolic acidosis
  •     The tests are preferred Kidney or abdominal ultrasound, but abdominal radiography, abdominal computed tomography scan or abdominal MRI can tell if there is a blockage in the urinary tract.
  •     Blood tests may help reveal the underlying causes of kidney failure.

Treatment
Once you have found the cause, the goal of treatment is to restore kidney function and prevent fluid and waste accumulate in the body while the kidneys heal. Generally, patients have to stay overnight in the hospital for treatment.
The amount of liquid that you take (such as soup) or drink will be limited to the amount of urine you can produce. You will be told what can and can not eat in order to reduce the accumulation of toxins normally handled by the kidneys. This diet can be rich in carbohydrates and low in protein, salt and potassium.
You may need antibiotics to treat or prevent infection and can be tested with diuretics to help the kidneys lose fluid.
It will be very important to avoid dangerous hyperkalemia (increased potassium levels in the blood) using calcium IV (intravenous), glucose / insulin or potassium exchange resin (Kayexalate).
Dialysis may be necessary and may make the person feel better. However, it is not always necessary but can save your life if serum potassium is dangerously high. Dialysis is also used if the person's mental status changes, your potassium level starts to rise, you stop urinating, develop pericarditis, fluid overload or it can not eliminate nitrogen waste from the body.Support Groups
The stress of illness can often be eased by joining a support group where members share common experiences and problems. View support group for kidney disease. The local hospital or dialysis center can probably specializes in providing information about local support groups.Expectations (prognosis)
Although acute renal failure is life threatening and may require intensive treatment, the kidneys usually start working again within a period of several weeks to months after the underlying cause treated.
In cases where this does not happen, has chronic renal failure or end-stage renal disease. Death can occur, but is most common when kidney failure is caused by surgery, trauma or severe infection in someone with heart disease, lung disease or recent stroke. Old age, infection, blood loss from the gastrointestinal tract and the progression of kidney failure also increase the risk of death. 

Complications
  •     Bleeding in the intestines
  •     Chronic renal failure (long)
  •     End-stage renal disease
  •     Damage to the heart or nervous system
  •     Hypertension (high blood pressure)

Calling your health care
Call your health care provider if absent or decreased urine output, or if you have other symptoms of acute renal failure.



PreventionThe treatment of disorders such as high blood pressure can help prevent acute renal failure. However, unfortunately, the prevention is not always possible.



source: clinicadam.com
READ MORE - Acute renal failure

Malabsorption can make the osteomalacia disease

Is difficulty digesting or absorbing nutrients from food.
Causes and Risk Factors

Malabsorption can result from a wide range of diseases. Typically, malabsorption can be the inability to absorb sugars, fats, proteins or vitamins, or they may also be a general malabsorption of food. Malabsorption may be accompanied by diarrhea, bloating or cramping, failure to thrive, frequent bulky stools, muscle atrophy and distension of the stomach.

Malabsorption can affect growth and development and can lead to specific diseases. Some causes of malabsorption include:

  •      Cystic fibrosis (the number one cause in the United States)
  •      chronic pancreatitis
  •      Lactose intolerance
  •      celiac disease
  •      Whipple's Disease
  •      Shwachman-Diamond syndrome (a genetic disease that affects the pancreas and bone marrow)
  •      Protein intolerance of cow's milk
  •      Intolerance to milk protein soy
  •      biliary atresia
  •      abetalipoproteinemia
     Malabsorption of vitamin B-12 due to:
  •          Diphyllobothrium latum infestation
  •          Juvenile pernicious anemia
  •      vermin
  •          Giardia lamblia
  •          Strongyloides stercoralis
  •          Necator americanus (hookworm)

symptoms

  •      Avoiding specific foods
  •      chronic diarrhea
  •      Bloating and gas
  •      Growth retardation

Signs and tests

See the individual conditions.
treatment

See the individual conditions.
Expectations (prognosis)

See the individual conditions.
complications

Malabsorption may lead to prolonged malnutrition and vitamin deficiencies.
Calling your health care

Call your health care provider if you notice symptoms of malabsorption.
prevention

See the individual conditions.



source: clinicadam.com
READ MORE - Malabsorption can make the osteomalacia disease

Rickets and the efect

Rickets
It is a disorder primarily caused by lack of vitamin D, calcium or phosphate, which leads to softening and weakening of bones.Alternative Names
Vitamin D deficiency, osteomalacia in children, renal ricketsCauses and Risk Factors
Vitamin D helps the body properly control calcium and phosphorus levels in the body. When the body lacks vitamin A, is unable to adequately control the levels of these minerals. If the blood levels of these minerals become too low, the body may produce other body hormones to stimulate release of calcium and phosphate from the bones, which leads to weak and soft bones present.
Vitamin D can be absorbed from food or produced by the skin when it is exposed to sunlight. Lack of vitamin D production by the skin can occur if the person is confined indoors, work indoors during daylight hours or live in climates with little exposure to sunlight.
Because vitamin D is a fat soluble vitamin, malabsorption disorders that reduce digestion or absorption of fats will decrease the ability of vitamin D to be absorbed into the body.
Deficiency of vitamin D in the diet can occasionally be seen in vegetarians, who do not drink milk products, or those who have lactose intolerance (those who have trouble digesting dairy products). Babies fed exclusively on breast milk may also develop vitamin D deficiency, because the milk does not supply the proper amount of the vitamin. This can be a particular problem for darker-skinned children in winter months when sunlight levels lower.
Inadequate intake of calcium and phosphorus in the diet can also lead to rickets. Rickets caused by a dietary lack of these minerals is rare in developed countries because calcium and phosphorus found in milk and green leafy vegetables.
Your genes may increase your risk of rickets. Hereditary rickets is a disease that is transmitted through families and occurs when the kidneys are unable to retain phosphorus. Rickets may also be caused by kidney disorders involving renal tubular acidosis.
Occasionally, rickets may also occur in children who have liver problems or can not convert vitamin D to its active form.
Rickets is rare in the United States. Most likely to occur during periods of rapid growth when the body demands high levels of calcium and phosphorus. It is usually seen in children 6 to 24 months of age and is uncommon in newborns.Symptoms

    
Bone pain or tenderness
        
arms
        
legs
        
column
        
pelvis
    
Skeletal deformities
        
bowlegged
        
forward projection of the breastbone (pigeon chest)
        
Bumps in the rib cage (rachitic rosary)
        
Skull asymmetrical or odd-shaped
        
spinal deformities (spine curves abnormally, including scoliosis or kyphosis)
        
Pelvic deformities
    
Increased tendency toward bone fractures
    
Dental deformities
        
Delayed formation of teeth
        
defects in the structure of teeth, holes in the enamel
        
increased incidence of tooth decay (dental caries)
        
progressive weakness
        
decreased muscle tone (loss of muscle strength)
    
Muscle cramps
    
Poor growth
    
Short stature adults within 1.52 m (5 ft) high
Signs and tests
A physical exam reveals tenderness or pain in the bones, rather than in the joints or muscles.
The following tests may help diagnose rickets:

    
Blood tests (serum calcium) may show low levels of calcium.
        
tetany (prolonged muscle spasm) which may occur if serum levels of calcium are low
        
Chvostek's sign may be positive (a spasm of facial muscles when facial nerve is tapped) indicating low serum calcium levels
    
Serum phosphorus may be low.
    
Serum alkaline phosphatase may be high.
    
Arterial blood gases may reveal metabolic acidosis.
    
X-rays of the bones may show loss of calcium from bones or changes in form or structure of these.
    
A bone biopsy is rarely performed but will confirm rickets.
Other tests and procedures include the following:

    
PTH
    
Urine calcium
    
Calcium (ionized)
    
Isoenzyme of ALP (alkaline phosphatase)
Treatment
The goal of treatment is to relieve symptoms and correct the cause of this condition. You must treat the underlying cause to prevent recurrence.
With the replacement of deficient calcium, phosphorus or vitamin D will eliminate most symptoms of rickets. Dietary sources of vitamin D include fish, liver and processed milk. It is recommended that exposure to moderate amounts of sunlight. Treating rickets caused by metabolic abnormalities may require a special prescription for vitamin D.
Good posture and the use of braces to help reduce or prevent deformities. In addition, you may need surgical correction of some skeletal deformities.Expectations (prognosis)
The disorder can be corrected with replacement of minerals and vitamin D deficient. Laboratory values ​​and x-rays usually improve after almost a week of treatment, although some cases may be resistant and require large doses of minerals and vitamin D.
If rickets is not corrected while children are still growing, skeletal deformities and short stature may be permanent. Conversely, if it is corrected while the child is young, skeletal deformities often diminish or disappear over time.Complications

    
Chronic skeletal pain
    
Skeletal deformities
    
Skeletal fractures, may occur without cause
Calling your health care
Call your pediatrician if you notice symptoms of rickets.Prevention
Rickets may be avoided by having your child maintain an adequate intake of calcium, phosphorus and vitamin D. This may require dietary supplementation in people with gastrointestinal disorders or other conditions, which you should consult your pediatrician.
The renal causes of malabsorption of vitamin D should be treated promptly and levels of calcium and phosphorus should be monitored regularly in people with kidney disease.
Genetic counseling can help people with a family history of inherited disorders that can cause rickets.



source: clinicadam.com
READ MORE - Rickets and the efect

Calcium in diet

Calcium in diet
Calcium is the most abundant mineral found in the human body, with teeth and bones contain the most calcium (about 99%). Body tissue, neurons, blood and other body fluids contain the remaining calcium.Alternative Names

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